Controlled release corticosteroid compositions and methods for the treatment of otic disorders

摘要

Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

主权项

1. A method of ameliorating an inner ear disease or disorder in a patient in need thereof comprising injecting through the tympanic membrane into the middle ear cavity of the patient a controlled release composition comprising dexamethasone and a thermosetting polymer; wherein the dexamethasone is uncoated and is suspended in the composition, and the thermosetting polymer is poloxamer 407 at a concentration of at least 10% w/w and up to 20% w/w, and wherein a single dose of the controlled release composition in the syringe is from 300 μL to 500 μL.