| 摘要 |
<p>Analogues of bovine and human parathyroid hormone, wherein the twenty-third amino acid of the natural hormone, tryptophane, has been substituted with Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Ile, Lys, Met, Pro, Ser or Thr have been found to retain bone cell effect with minimal effects on blood pressure and smooth muscle, including cardiac muscle. It has further been found that this effect can be obtained by using a synthetic PTH containing only the first 34 amino acids of PTH, with substitution at the twenty-third amino acid as described. These analogues of PTH also are effective in the treatment of osteoporosis and other bone diseases.</p> |
