SYSTEMS AND METHODS OF CHOROIDAL NEOVASCULARIZATION DETECTION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

摘要

Disclosed are systems and methods to automatically detect choroidal neovasculatization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.

主权项

1. A method of measuring choroidal neovascularization (CNV) area in an OCT angiogram comprising:
receiving a set of OCT angiograms; separating the set of cross sectional-OCT angiograms into an inner set of retina angiograms, the inner set of retina angiograms comprising angiograms located between an internal limiting membrane and an outer plexiform layer, and an outer set of retina angiograms, the outer set of retina angiograms comprising angiograms located between the outer plexiform layer and Bruch's membrane; projecting the maximum flow values of the inner set of retina angiograms along the axial (Z) direction onto an X-Y plane, thereby generating a single 2D en face inner retina angiogram; projecting the maximum flow values along the axial (Z) direction of the outer set of retina angiograms onto an X-Y plane, thereby generating a single 2D en face outer retina angiogram; applying a denoising filter to the inner retina angiogram, thereby generating a denoised inner retina angiogram; subtracting the denoised inner retina angiogram from the outer retina angiogram; thereby removing projection artifacts from the outer retina angiogram; generating a saliency map of CNV in the outer retina angiogram using pattern recognition; generating a binary vascular mask from the saliency map; multiplying the binary vascular mask by the original 2D en face outer retina angiogram, thereby identifying the CNV region in the outer retina angiogram; and calculating the CNV area.