BISPECIFIC FUSION PROTEINS FOR ENHANCING IMMUNE RESPONSES OF LYMPHOCYTES AGAINST TUMOR CELLS

摘要

The present invention relates to recombinant fusion proteins. Said fusion protein comprises a binding protein with a binding site that specifically binds to a receptor specific for T cells or natural killer cells, an extracellular fragment of a transmembrane protein that is an immune receptor and that binds to a target cell or to a ligand or antigen expressed by a target cell, and a linking polypeptide connecting the binding protein and the extracellular fragment of a transmembrane protein, wherein said polypeptide comprises at least a portion of a Fc domain. The invention further relates to uses of said fusion proteins, such as medical uses. Furthermore, the invention relates to nucleic acids encoding for said fusion proteins, host cells comprising said nucleic acids, and methods of production of said fusion proteins.