Methods and compositions are described for the preparation of bioactive agents entrapped in lipid vesicles the bilayers of which comprise a salt form of an organic acid derivative of a sterol, such as the tris-salt form of a sterol hemisuccinate, and to compositions comprising a mixture of tris(hydroxymethyl)aminomethane salt of cholesteryl hemisuccinate with either an antifungal compound or a peptide. These compositions have various applications in vivo.
申请公布号
US5288499(A)
申请公布日期
1994.02.22
申请号
US19910758587
申请日期
1991.09.12
申请人
THE LIPOSOME COMPANY, INC.
发明人
JANOFF, ANDREW S.;POPESCU, MIRCEA C.;WEINER, ALAN L.;BOLCSAK, LOIS E.;TREMBLAY, PAUL A.;SWENSON, CHRISTINE E.