ANTIATHEROSCLEROTIC DIARYL COMPOUNDS

摘要

The present invention is concerned with compounds of formula (I) wherein m is 0 or 1; W is hydrogen, a C1-16 straight, branched, or cyclic alkyl group, or a C2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph(CH2)n- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C1-4 alkoxy and C1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, or R<1>NHCO- where R<1> is hydrogen or a C1-6 alkyl group, or R<2>CONH- where R<2> is hydrogen or a C1-6 alkyl group; X is -(CH2)pNHCO @H, where p is an integer of from 0 to 2, -NHCONH @H2, -CO @H, -NHCO @H2, -NHCO @, -CS @H, -NHCS@H, -NHC(:NH) @H, -NHC(:NCN) @H, -NHC(:CHCN) @H, -NHC(:CHNO2) @H, or -CH(A)CO@H where A is halogen; Y is -(CH2)q, where q is an integer of from 1 to 3, or -CH=CH- (E or Z); Z is a C1-6 alkyl group optionally substituted by one or more independently selected polar groups; and ring A is optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C1-4 alkoxy and C1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen; provided said compound of formula (I) is not N-{2-[(4-methylphenyl)methyl]phenyl}acetamide or alpha -(p-tolyl)-o-cresol carbanilate; and salts, solvates and physiologically functional derivatives thereof, processes for the preparation of these compounds, pharmaceutical formulations containing them and their use in medicine.