发明名称 |
Analogs of human granulocyte-macrophage colony stimulating factor |
摘要 |
Amplified expression of recombinant DNA products is achieved in hosts expressing proteases that cleave at multi-basic amino acid residues. To this end, cDNAs encoding granulocyte-macrophage colony stimulating factor (GM-CSF) are mutated such that one or both of the arginine residues at positions 23 and 24 of the protein product are deleted or replaced by non-basic amino acid residues. The GM-CSF analogs thus obtained maintain the activity of the wild-type protein.
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申请公布号 |
US5393870(A) |
申请公布日期 |
1995.02.28 |
申请号 |
US19930067934 |
申请日期 |
1993.05.27 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
DEELEY, MICHAEL C.;PRICE, VIRGINIA L. |
分类号 |
C12N15/09;A61K35/74;A61K38/16;C07K14/00;C07K14/52;C07K14/53;C07K14/535;C12N1/16;C12N15/00;C12N15/10;C12N15/27;C12P21/00;C12P21/02;C12R1/865;(IPC1-7):C07K13/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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