Modified oligonucleotides, method for producing them and use as active substances

摘要

The invention pertains to 10 to 50-mer oligonucleotides which, with the attachment of appropriate radicals that carry basic groups, are capable of forming amphoteric ions via intramolecular ammonium salts. Oligonucleotides modified in this way do not lose their ability to pair with their complementary strand. Such oligonucleotides can be expected to show a greater nuclease resistance and better membrane penetrability than natural oligonucleotides. This yields important benefits for antisense therapy.