PRODUCTS COMPRISING SUBSTRATES CAPABLE OF ENZYMATIC CROSS-LINKING

摘要

Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences capable of enzyme catalyzed covalent bond formation for cross-linking, as exemplified by glutamine and/or lysine reactive for FXIII catalyzed isopeptide formation or non-amino acid polymers having side chains comprising such amino acids or sequences, which may be used for preparation of articles of manufacture, particularly cross-linkable compositions. By appropriate choice of the polymer, restorable implantable polymers may be used in internal applications for mammals as formed objects or depots.