ANTI-IDIOTYPIC ANTIBODY INDUCTION OF ANTITUMOR RESPONSE.
摘要
<p>Novel compositions and methods are described for stimulating a patient's immune system to tumor cells which bear a gp72 tumor-associated antigen and thereby eliciting a tumoricidal effect. Anti-idiotypic human monoclonal antibodies and idiotopic regions thereof to primary antibodies which bind selectively to an antigenic determinant of gp72 are provided to mediate the humoral and cellular components of the patient's immune system. The immunogenic agents find use both in vivo and in vitro.</p>
申请公布号
EP0440689(B1)
申请公布日期
1995.11.29
申请号
EP19890911726
申请日期
1989.10.13
申请人
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED
发明人
BALDWIN, ROBERT, WILLIAM;DURRANT, LINDA, GILLIAN;AUSTIN, ERIC, BERTRAM;BYERS, VERA, S.