发明名称 |
Mammalian primate erythrocyte bound heteropolymerized monoclonal antibodies and methods of use thereof |
摘要 |
Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.
|
申请公布号 |
US5487890(A) |
申请公布日期 |
1996.01.30 |
申请号 |
US19940186136 |
申请日期 |
1994.01.24 |
申请人 |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION |
发明人 |
TAYLOR, RONALD P.;SUTHERLAND, WILLIAM M.;REIST, CRAIG;WRIGHT, ELEANOR L.;WEBB, DONNA;LABUGUEN, RONALD |
分类号 |
A61K35/18;A61K38/00;A61K47/48;C07K16/28;(IPC1-7):A61K39/395;A61K39/40;A61K39/42 |
主分类号 |
A61K35/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|