| 摘要 |
The prepn. of 5-chloro-4-(2-imidazolin-2-yl-amino) 2,1,3-benzo thiadiazole (I) comprises reacting 5-chloro-4-cyanamino -2,1,3-benzothiadiazole (II) with ethylene diamine-mono-p-toluene sulphonate in xylene. - Reaction is at 75-140, pref. 80-110 deg.C, esp. 90-100 deg.C. USE/ADVANTAGE - (I) is a centrally effective myotonolytic. Pure crystalline (I) can be obtd. simply and in very good yields. The process can be carried out on an industrial scale in a single pot and uses no pollutants or hard-to-handle solvents. The process is economical, in that yields are high, energy requirements are low and the solvent is cheap, and does not need to be evapd. off. |
