| 发明名称 |
EPITOPES OF HERPES SIMPLEX VIRUS |
| 摘要 |
The present invention relates to diagnosis, prevention and treatment of Herpes simplex viruses and infection. In particular embodiments the present invention relates to methods and compositions for the prophylactic or therapeutic immunization against of infections of HSV. The present invention also relates to methods and compositions for diagnosis of the presence of and level of immunity to HSV. The invention also relates to peptide epitopes of HSV, in particular peptide epitopes of HSV2 glycoprotein D, to compositions thereof and to the use of such epitopes and compositions in methods for diagnosis, prevention and treatment of HSV. |
| 申请公布号 |
US2016317649(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615157181 |
申请日期 |
2016.05.17 |
| 申请人 |
Sydney West Area Health Service ;The University of Sydney |
发明人 |
Cunningham Anthony Lawrence;Kim Min |
| 分类号 |
A61K39/245;C07K14/005;G01N33/569;C07K16/08;C12P21/00;C12N7/00;C07K14/195 |
主分类号 |
A61K39/245 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein, comprising:
(a) at least one immunogenic Herpes simplex virus (HSV) glycoprotein D peptide consisting of 23 amino acids or less and having at least 6 amino acids, said peptide comprising an amino acid sequence selected from the group consisting of SEQ ID Nos: 1-5, SEQ ID Nos: 9-12, SEQ ID Nos: 23-27, SEQ ID Nos: 29-31 and SEQ ID Nos: 33-37, or an immunogenic fragment thereof; and (b) a lipopeptide, wherein said HSV glycoprotein D peptide is conjugated to the lipopeptide. |
| 地址 |
Westmead AU |
