| 摘要 |
PURPOSE: To obtain a partially methylatedβ-cyclodextrin having a water solubility being higher than that of a perfectly methylated product and increasing with an increasing temperature by specifying its Rf value and specifying the degrees of methylation of the respective hydroxyl groups of a structural glucose unit. CONSTITUTION: This partially methylatedβ-cyclodextrin is one represented by the formula (wherein R is H or CH3 ), having an Rf value of 0.30 when analyzed by silica gel thin-layer chromatography and having the following degrees of methylation of the respective hydroxyl groups of a structural glucone unit: 52.8% at position 2, 40.6% at position 3 and 77.4% at position 6 when they are estimated by gas chromatography after the pretreatment. Cyclodextrin (hereinbelow abbreviated as CD) is difficultly soluble in water and an organic solvent. Although known perfectly methylatedβ-CD has an improved water solubility, it has a drawback that its solubility decreases with an increasing temperature. The above partially methylatedβ-CD has a water solubility being higher than that and increasing contrarily with an increasing temperature.
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