ANTI-METASTATIC AND ANTI-ANGIOGENIC PHARMACEUTICAL COMPOSITIONS

摘要

The present invention concerns novel pharmaceutical compositions for the treatment of cancer, either by inhibition of the tumor metastatic tendency or alternatively by inhibiting formation of new blood vessels (angiogenesis) and thus depriving the tumor from its blood source. The active compound in the pharmaceutical compositions of the invention is a fragment of the Thrombin Bchain comprising the sequence Arg-Gly-Asp in an exposed orientation, or modified thrombin in which the naturally cryptic Arg-Gly-Asp sequence has been modified so that it is in an exposed orientation.