| 摘要 |
A camptothecin derivative comprising a compound of the formula ¢I!: <IMG> ¢I! wherein R1 is a substituted or unsubstituted lower alkyl group, X1 is a group of the formula: -NHR2(R2 is a hydrogen atom or a lower alkyl group) or a group of -OH, and Alk is a straight chain or branched chain alkylene group having optionally an oxygen atom in the chain thereof, bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects unlike conventional anticancer agents, and hence, these compounds are extremely useful as a medicament.
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