发明名称 |
HEPATITIS B VACCINE. |
摘要 |
<p>A variant and so-called "escape mutant" HBsAg protein or fragment thereof displaying the antigenicity of hepatitis B virus surface antigen is disclosed, in which the mutant protein or fragment thereof (mHBsAg) comprises a modified 'a' determinant in which at least two amino acids are inserted downstream of position (122) of the wild type HBsAg sequence. A vaccine comprising the mHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-mHBsAg antibodies and an antibody preparation comprising anti-mHBsAg antibodies.</p> |
申请公布号 |
MX9603182(A) |
申请公布日期 |
1997.05.31 |
申请号 |
MX19960003182 |
申请日期 |
1995.02.02 |
申请人 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & ME;DICINE |
发明人 |
PETER KARAYIANNIS;HOWARD CHRISTOPHER THOMAS |
分类号 |
G01N33/576;A61K39/00;A61K39/29;A61P31/12;C07H21/04;C07K14/02;C07K16/08;C12N15/09;(IPC1-7):C07K14/02 |
主分类号 |
G01N33/576 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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