发明名称 |
Human cancer inhibitory peptide amides |
摘要 |
This application discloses seven newly synthesized pentapeptide amides and four tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino acids are constituents of the well known dolastatin 10 and dolastatin 15 which are structurally distinct peptides with excellent antineoplastic activity. These peptides were constructed by introducing a peptide bond between selected amino acids and modified amino acids and coupling the resulting di- and tri-peptides to obtain peptides having a high anticancer activity against a series of human cancer cell lines. <IMAGE>
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申请公布号 |
US5665860(A) |
申请公布日期 |
1997.09.09 |
申请号 |
US19960671121 |
申请日期 |
1996.06.13 |
申请人 |
ARIZONA BOARD OF REGENTS ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY |
发明人 |
PETTIT, GEORGE R.;SRIRANGAM, JAYARAM K.;WILLIAMS, MICHAEL D. |
分类号 |
A61K38/00;A61K35/56;A61P35/00;C07K5/02;C07K5/027;(IPC1-7):A61K38/04;C07K5/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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