发明名称 |
Inhibition of signal transduction by the binding of non-phosphorylated compositions |
摘要 |
A non-phosphorylated peptide or functionally equivalent composition binds to an SH2 domain of a signal transduction protein with high affinity. In particular, the composition binds to the SH2 domain with an affinity similar to that of at least one phosphorylated peptide that is a natural target for the protein. The inhibition of a signal transduction process can be accomplished by administering a non-phosphorylated peptide or functionally equivalent composition. |
申请公布号 |
AU3884797(A) |
申请公布日期 |
1998.02.09 |
申请号 |
AU19970038847 |
申请日期 |
1997.07.16 |
申请人 |
GEORGETOWN UNIVERSITY;UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE |
发明人 |
C. RICHTER KING;LAKSHMI SASTRY;DAVID KRAG;LYN OLIGINO |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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