| 摘要 |
Methods of and formulations for administering acid addition salts of compounds of Formula (A) or Formula (B), wherein R1 comprises an aryl or alkyl group with a hydrogen bond acceptor site accessible to interaction with said tertiary nitrogen of Formula (A) or said quaternary ammonium ion of Formula (B), R2, R3 and R4 are alkyl or aryl groups, and X<-> is an anion. In the methods, a sterile injectable formulation of a liquid vehicle containing the acid addition salt in solution is adjusted in pH for reducing the development of undesirable side effects of the material or provided at a pH within a range of about 5.5 to 7.0, and administering these acid addition salts by intramuscular injection contain the salt at a concentration of at least about 50 mg/ml and are at a pH within a range of about 5.5 to 7.0. |
