发明名称 NEW SAPONIN DERIVATIVE DERIVED FROM PANAX NOTOGINSENG
摘要 PROBLEM TO BE SOLVED: To obtain the subject new compound having hemostatic action, antiinflammatory action and analgesic action, useful as a therapeutic agent for various diseases for which Panax notoginseng has been used, especially hepatic failure, an antiinflammatory agent, etc., comprising a specific saponin glycoside isolated from Panax notoginseng as a Chinese medicine. SOLUTION: This new saponin glycoside is shown by formula I [R<2> is Glu<6> -<1> Glu (Glu is /β-D-glucopyranosyl and the numbers on the shoulder mean their bonded positions); R<2> is Glu<2> -<1> Glu; R<3> is a group of formula II, formula III, etc.], has hemostatic action, antiinflammatory action and analgesic action and is useful for various diseases for which Panax notoginseng has been used. The compound is obtained by extracting Panax notoginseng as a Chinese medicine with methanol in a hot state, partitioning the extracted essence with ethyl acetate and methanol in a liquid-liquid state, adding n-butanol to its water transfer part, carrying out the liquid-liquid partition of the water transfer part and subjecting the n-butanol phase to normal phase silica gel chromatography and reversed phase column chromatography.
申请公布号 JPH1087691(A) 申请公布日期 1998.04.07
申请号 JP19960239047 申请日期 1996.09.10
申请人 TEIKOKU SEIYAKU CO LTD 发明人 YOSHIKAWA MASAYUKI;MURAKAMI KEIJU;UENO TAKAHIRO;YAMAHARA JOJI;SAIJO REIKO
分类号 A61K31/575;C07J9/00;(IPC1-7):C07J9/00 主分类号 A61K31/575
代理机构 代理人
主权项
地址