发明名称 |
METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY |
摘要 |
Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof. |
申请公布号 |
US2016317510(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
US201514958103 |
申请日期 |
2015.12.03 |
申请人 |
Sunesis Pharmaceuticals, Inc. |
发明人 |
SILVERMAN Jeffrey A. |
分类号 |
A61K31/4375;A61K31/7068;A61K9/00;A61K45/06;A61K33/24;A61K31/555 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating cancer comprising administering a dose of about 1 mg/m2 to about 150 mg/m2 of (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid and/or a pharmaceutically acceptable salt or hydrate thereof and a dose of about 5 mg/m2 to about 200 mg/m2 cisplatin. |
地址 |
South San Francisco CA US |