| 发明名称 |
CONJUGADOS QUE CONTIENEN UN AGENTE CITOTOXICO UNIDO A UN OLIGOPEPTIDO |
| 摘要 |
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
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| 申请公布号 |
PE17399(A1) |
申请公布日期 |
1999.02.20 |
| 申请号 |
PE19970000970 |
申请日期 |
1997.10.29 |
| 申请人 |
MERCK AND CO., INC. |
发明人 |
GARSKY, VICTOR M.;FENG, DONG-MEI;DEFEO-JONES, DEBORAH |
| 分类号 |
C07K7/06;A61K31/337;A61K31/407;A61K31/475;A61K31/513;A61K31/517;A61K31/675;A61K31/704;A61K31/7048;A61K31/7064;A61K38/00;A61K38/08;A61K47/48;A61P13/08;A61P35/00;C07K7/08;C07K14/47 |
主分类号 |
C07K7/06 |
| 代理机构 |
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