CHROMAN DERIVATIVE CONTAINING OPHTHALMIC SOLUTION

摘要

The object of the present invention is to provide an ophthalmic solution with improvement in the ocular penetration of (2S, 4S)-6-fluoro-2',5'-dioxospiro¢chroman-4,4'-imidazolidine!-2-carboxamide as an active ingredient. The ophthalmic solutior of the present invention comprises (2S, 4S)-6-fluoro-2',5'-dioxospiro¢chroman-4,4'-imidazolidine!-2-carboxamide as an active ingredient whereln the osmotic pressure ratio is adjusted to less than 1 and the viscosity to more than 1 cP thereby ocular penetration of the active ingredient are remarkably improved. As a viscosity increasing agent, a cellulose-based polymer for example is formulated. The cellulose-based polymer is preferably hydroxypropylmethylcellulose.