System and method for calibrated spectral domain optical coherence tomography and low coherence interferometry

摘要

Systems and methods for enhancing spectral domain optical coherence tomography (OCT] are provided. In particular, a system and method for calibration of spectral interference signals using an acquired calibration signal are provided. The calibration signal may be logarithmically amplified to further improve the accuracy of the calibration. From the calibration signal, a series of more accurate calibration data are calculated. An acquired spectral interference signal is calibrated using these calibration data. Moreover, systems that include logarithmic amplification of the spectral interference signal and variable band-pass filtering of the spectral interference signal are provided. Such systems increase the dynamic range and visualization capabilities relative to conventional spectral domain OCT systems.

主权项

1. An optical coherence tomography system comprising:
a light source configured to produce light to illuminate a sample with the sample light; at least one optical path configured to receive at least one of reference light and sample light from the light source and to illuminate a sample with the received sample light; a detector in optical communication with the at least one optical path and configured to receive the reference and sample light; a processor coupled to the detector and the light source and configured to:
a) receive a signal from the detector;b) determine, from the received signal, an interference signal related to the reference light and the sample light;c) receive a calibration signal from the light source;d) identify at least one of a series of extrema and a series of crossing values in the received calibration signal;e) identify at least one of a series of calibration extrema and a series of calibration crossing values from the received calibration signal and the identified at least one of series of extrema and series of crossing values by performing an interpolation;f) calibrate the interference signal using the identified at least one of a series of calibration extrema and series of calibration crossing values; andg) reconstruct an image of the sample from the recalibrated interference signal.