A NOVEL PROCESS FOR THE PREPARATION OF ETHACRYNATE SODIUM

摘要

The present invention describes a novel process for the preparation of Ethacrynate sodium. The process involves the treatment of Ethacrynic acid with equimolar amount of sodium salt of alkyl carboxylic acid in the presence of organic solvents. The product obtained by the process is substantially pure form (purity greater than 99%) and limits known impurities below 0.1% w/w. The process also relates to a crystalline form of Ethacrynate sodium and a process for its preparation. The process is efficient and cost effective method for the commercial scale production of substantially pure stable form of Ethacrynate sodium.