发明名称 |
METHOD OF PREPARING 3-AZABICYCLO [3,3,1] NONANE DERIVATIVES |
摘要 |
FIELD: chemical industry. SUBSTANCE: new method of preparing new 3-azabicyclo [3,3,1] nonane derivatives of general formula I: <EMI ID=0.9 HE=27 WI=36 TI=CHI> wherein or ¼ wherein n is 2,4 or 6 using Mannich reaction comprises reducing original èéì<SB>4</SB>-dinitrobenzene with <EMI ID=0.10 HE=12 WI=66 TI=CHI> to 3,5- bis(acy-nitro)cyclohexene-1 dipotassium salt of formula A: <EMI ID=0.11 HE=27 WI=42 TI=CHI>. This salt is reacted with mixture of formaldehyde and primary amine, and the reaction solution is subsequently acidified with acetic acid to pH of 6 to prepare compounds of formula I wherein R is <EMI ID=0.12 HE=24 WI=36 TI=CHI> or is reacted with mixture of formaldehyde and diamine and the reaction solution is subsequently acidified with acetic acid to pH of 6 to prepare compounds of formula I wherein R is <EMI ID=0.13 HE=24 WI=42 TI=CHI> wherein n is 2,4 or 6. EFFECT: new compounds with valuable properties. 3 ex
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申请公布号 |
RU2132846(C1) |
申请公布日期 |
1999.07.10 |
申请号 |
RU19970120879 |
申请日期 |
1997.12.15 |
申请人 |
TUL'SKIJ GOSUDARSTVENNYJ PEDAGOGICHESKIJ UNIVERSIT;TUL SKIJ G PED UNIVERSIT |
发明人 |
ATROSHCHENKO JU.M.;NIKIFOROVA E.G.;GITIS S.S.;SHAKHKEL'DJAN I.V.;SUBBOTIN V.A. |
分类号 |
C07D221/22;(IPC1-7):C07D221/22 |
主分类号 |
C07D221/22 |
代理机构 |
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