| 摘要 |
A method for preparing N2-(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-NG-nitro-L-arginine which comprises the step of condensing NG-nitro-L-arginine and 3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl chloride. The method achieves an extremely efficient and high yield preparation of N2-arylsulfonyl-L-arginineamides that are useful as active ingredients of medicaments. Also provided is a novel N2-(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-NG-nitro-L-arginine compound which can be used as synthetic intermediate for the manufacture of (2R,4R)-4-methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidine-carboxylic acid.
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