| 发明名称 |
Method of inhibiting photoaging of skin |
| 摘要 |
<p>Photoaging of undamaged skin due to UVB irradiation exposure is inhibited by administering an agent that inhibits at least one of (1) the activity of UVB irradiation inducible MMPs in the skin, (2) one or both of the transcription factors AP-1 and NF- B or (3) at least one of the GTP binding proteins or kinases involved in the activation and/or production of jun of fos proteins that comprise AP-1; and topically administering said inhibitor to the skin prior to such exposure.</p> |
| 申请公布号 |
SI9720015(A) |
申请公布日期 |
1999.10.31 |
| 申请号 |
SI19970020015 |
申请日期 |
1997.01.17 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
VOORHEES JOHN J.;FISHER GARY J. |
| 分类号 |
A61K8/60;A61K8/00;A61K8/33;A61K8/46;A61K8/58;A61K8/67;A61K31/00;A61K31/16;A61K31/20;A61K31/203;A61K31/352;A61K31/381;A61K31/4045;A61K31/57;A61K31/573;A61K31/59;A61K31/593;A61K45/00;A61P17/00;A61Q19/00;A61Q19/08;(IPC1-7):A61K7/40;A61K7/42 |
主分类号 |
A61K8/60 |
| 代理机构 |
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代理人 |
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| 主权项 |
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