HEPTAPEPTIDE OXYTOCIN ANALOGUES

摘要

Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal beta-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the beta-aminoalcohol Z is -NR-CH(Q)-CH 2 OH, Q is (CH 2 ) n -NH-A, n is 1-6 and A is H or -C(=NH)NH 2 , and R is CH 3 or C 2 H 5 , and the moiety S wherein X is a D-aromatic alfa-aminoacid and Y is an aliphatic alfa-aminoacid, and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions.