| 摘要 |
FIELD: pharmaceutical chemistry. SUBSTANCE: new guanidine derivatives with formula I: <EMI ID=0.313 HE=27 WI=36 TI=CHI> (I) are provided where Y is nitrogen or group C-R (R is hydrogen, lower alkyl, hydroxyl, etc.); R is hydrogen, optionally substituted aryl, aryloxy group, etc.; R hydrogen, lower alkoxy, hydroxyl, etc.; Z nitrogen or C-R (R is hydrogen, halogen, hydroxyl, lower alkyl, etc. ); and W nitrogen or C-R (R is hydrogen) and their pharmaceutical acceptable salts. Compound of invention are useful as drugs in treatment and/or prophylactics of cardiac infarction or ischemic disease. Method of preparing these compounds is also provided. EFFECT: extended choice of cardiovascular medicines. 15 cl, 1 tbl, 34 ex
|
