发明名称 16-Hydroxyestratriene als selektiv wirksame Estrogene
摘要 The invention relates to novel compounds as pharmaceutical agents which have in vitro a higher affinity to estrogen receptor preparations of the rat prostate than to estrogen receptor preparations of the rat uterus and which preferably have in vivo a preferential effect on bones as compared to the uterus and/or a marked effect with regard to the stimulation of the expression of the 5HT2a receptor and transporter. The invention also relates to the production and to the use in therapy of these compounds and to pharmaceutical administration forms containing said novel compounds. The novel compounds are 16 alpha and 16 beta hydroxy-estra,1,3,5(10)-estratriene which carry additional substituents at the steroid backbone and one or more additional double bonds on the B, C and/or D rings.
申请公布号 DE19906159(A1) 申请公布日期 2000.08.10
申请号 DE19991006159 申请日期 1999.02.09
申请人 SCHERING AG 发明人 KUENZER, HERMANN;KNAUTHE, RUDOLF;LESSL, MONIKA;FRITZEMEIER, KARL-HEINRICH;HEGELE-HARTUNG, CHRISTA;BOEMER, ULF;MUELLER, GERD;KOSEMUND, DIRK
分类号 A61K31/565;A61P1/00;A61P5/30;A61P9/00;A61P9/10;A61P13/00;A61P13/02;A61P13/08;A61P19/08;A61P19/10;A61P25/00;A61P25/20;A61P25/28;A61P29/00;A61P35/00;A61P37/00;C07J1/00;C07J15/00;C07J31/00;C07J33/00;C07J41/00;C07J53/00;(IPC1-7):C07J9/00;A61K31/575 主分类号 A61K31/565
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