| 摘要 |
PROBLEM TO BE SOLVED: To provide a method that comprises administering a prostaglandin agonist which is useful for preventing the decrease of bone, recovering or increasing the quantity of the bone, and promoting bone recovery including the treatments of states showing low bone quantity and/or bone defect in vertebrates, especially mammals including human being, and to provide a medicinal composition containing the prostaglandin agonist. SOLUTION: This method for treating a state showing a low bone quantity, especially osteoporosis, infirmitas, osteoporotic fracture, bone deficiency, idiopathic bone decrease of infant, alveolar bone decrease, mandible bone decrease, fracture, osteectomy, bone decrease related to periodontitis, or prothesis inner growth, comprising administering a prostaglandin agonist which is an EP4 receptor selective prostaglandin agonist. The EP4 receptor selective prostaglandin agonist is especially a compound of formula I (variables are as defined in the specification).
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