NOVEL PROCESS FOR PREPARING 4-SUBSTITUTED-1H-PYRROLE-3-CARBOXYLIC ACID ESTER

摘要

The present invention relates to a novel process for preparing pyrrole ester compounds, which are key intermediates in the preparation of farnesyl transferase inhibitors, an anti-cancer agent. Horner-Emmons reaction of aldehyde compounds provides the corresponding alpha , beta -unsaturated esters, which without any separation and/or purification steps, are treated with toluenesulfonylmethylisocyanate in the presence of base to give pyrrole esters in one-pot fashion.