发明名称 |
METHOD FOR PREPARING R- OR S- FORM - SUBSTITUTED HETEROCYCLIC CARBOXYL ACID DERIVATIVE USING ENZYME |
摘要 |
<p>Disclosed is a method for preparing an R- or S-forms of alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) and a counter enantiomeric form of alpha-substituted heterocyclic carboxylic acid ester thereto by use of an enzyme. A racemic alpha-HCCA is reacted with alcohol to give a racemic alpha-HCCA ester, which is then brought into contact with an enzyme with enantioselectivity, whereby either R-form or S-form of the racemate is hydrolyzed. Extraction with an organic solvent can obtain enantiomers of the alpha-HCCA ester. Thus, a certain enantiomeric form of alpha-HCCA and a counter enantiomeric form of alpha-HCCA ester thereto, respectively can be prepared with high optical purity at high yields as well as at low cost.</p> |
申请公布号 |
KR20010108982(A) |
申请公布日期 |
2001.12.08 |
申请号 |
KR20000030073 |
申请日期 |
2000.06.01 |
申请人 |
SK CORPORATION |
发明人 |
EOM, GI NAM;LIM, JONG HO;LIM, SANG CHEOL |
分类号 |
C12P7/40;C12P41/00;(IPC1-7):C12P7/40 |
主分类号 |
C12P7/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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