METHOD FOR THE FORMULATION OF SUBSTANCES HAVING A LOW WATER-SOLUBILITY AND LIPOPHILICITY AND FORMULATION THUS OBTAINED
摘要
The present invention relates to a method for encapsulating substances, in particular drugs, that have a low water-solubility and lipophilicity, which method comprises providing a lipid system comprising one or more negatively charged lipid(s); combining the lipid system with the substance(s) in a medium at a low total solutes concentration; subjecting the mixture thus obtained to one or more cycles of freezing and thawing to produce lipid-coated aggregates of the substance(s), and optionally removing the free (non-enclosed) substance(s). The method is in particular suitable for encapsulating cisplatin.
申请公布号
WO0132139(A3)
申请公布日期
2001.12.13
申请号
WO2000EP11236
申请日期
2000.11.06
申请人
SEED CAPITAL INVESTMENT-2 (SCI-2) B.V.;BURGER, KOERT, NICO, JAN;STAFFHORST, RUTGER, WILLIBRORDES, HENRICUS, MARIA;DE KRUIJFF, BEN
发明人
BURGER, KOERT, NICO, JAN;STAFFHORST, RUTGER, WILLIBRORDES, HENRICUS, MARIA;DE KRUIJFF, BEN