发明名称 |
HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL |
摘要 |
A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm<3> and deliver at least about 50 % of the mass of particles. The particles are capable of carrying agents. The agent is: 1) part of the spray-drying pre-mixture and thereby incorporated into the particles; 2) added to separately-prepared particles so that the agent is in chemical association with the particles; or 3) blended so that the agent is mixed with, and co-delivered with the particles. Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm<3> and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included. |
申请公布号 |
WO0195874(A2) |
申请公布日期 |
2001.12.20 |
申请号 |
WO2001US18491 |
申请日期 |
2001.06.08 |
申请人 |
ADVANCED INHALATION RESEARCH, INC.;EDWARDS, DAVID, A.;BATYCKY, RICHARD, P.;JOHNSTON, LLOYD |
发明人 |
EDWARDS, DAVID, A.;BATYCKY, RICHARD, P.;JOHNSTON, LLOYD |
分类号 |
A61K9/12;A61K9/00;A61K9/14;A61K9/16;A61K9/72;A61K31/137;A61K31/198;A61K31/46;A61K31/56;A61K38/27;A61K38/28;A61K39/395;A61L9/04;B05D7/14 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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