METHOD FOR PRODUCING CAMPHORSULTAM

摘要

PURPOSE: Provided is a method for producing camphorsultam and its intermediate which are useful as a reagent for asymmetric induction and as a starting material for a compound useful as a fine chemical or medicament. CONSTITUTION: The method for producing camphorsultam comprises the steps of: reacting camphorsulfonic acid with a halogenation agent to give camphorsulfonyl halide; reacting the camphorsulfonyl halide with ammonia to give camphorsulfonamide; subjecting the camphorsulfonamide to dehydration and ring closure to give camphorsulfonimine; and reducing the camphorsulfonimine with sodium borohydride in an aqueous isopropanol solution.