发明名称 |
TCF mutant |
摘要 |
The present invention relates to TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for various hepatic diseases and an antitumor agent.
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申请公布号 |
US2002165358(A1) |
申请公布日期 |
2002.11.07 |
申请号 |
US20020133912 |
申请日期 |
2002.04.25 |
申请人 |
DAIICHI PHARMACEUTICAL CO., LTD. |
发明人 |
KINOSAKI MASAHIKO;YAMAGUCHI KYOJI;KOBAYASHI FUMIE;GOTO MASAAKI;MURAKAMI AKIHIKO;UEDA MASATSUGU;HIGASHIO KANJI;YAMASHITA YASUSHI |
分类号 |
A61K38/00;C07K14/475;C12N15/19;(IPC1-7):C07K14/705;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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