| 发明名称 |
Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat |
| 摘要 |
The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.
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| 申请公布号 |
US2002165191(A1) |
申请公布日期 |
2002.11.07 |
| 申请号 |
US20020096549 |
申请日期 |
2002.03.11 |
| 申请人 |
THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES |
发明人 |
MOONEN CHRIT |
| 分类号 |
C12N15/09;A61K38/22;A61K48/00;A61P35/00;C07K14/52;C07K14/54;C12N15/85;C12N15/861;(IPC1-7):A61K48/00;A61F7/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
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