发明名称 |
Mutated class II major histocompatibility proteins |
摘要 |
Provided are methods for directed mutagenesis and selection of MHC Class II proteins and single chain proteins with improved conformational stability and/or binding affinity for at least one cognate ligand. The improved proteins are useful for identification of T cells that are specific for the MHC Class II proteins and for treatment of disorders including autoimmune diseases, with the disorder determining the choice of the particular improved protein, peptide-protein complex or other ligand protein complex.
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申请公布号 |
US2002165149(A1) |
申请公布日期 |
2002.11.07 |
申请号 |
US20010015536 |
申请日期 |
2001.12.10 |
申请人 |
KRANZ DAVID M.;STARWALT SCOTT;BLUESTONE JEFFREY A. |
发明人 |
KRANZ DAVID M.;STARWALT SCOTT;BLUESTONE JEFFREY A. |
分类号 |
C07K14/705;C07K14/74;C12N15/10;C40B40/02;(IPC1-7):A61K38/17;G01N33/53;C12N1/18;C12P21/02 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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