Novel human monocyte chemotactic proprotein

摘要

The present invention provides a polynucleotide which identifies and encodes a novel human monocyte chemotactic proprotein (MCPP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCPP. The invention also provides for the use of substantially purified MCPP and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of MCPP. Additionally, the invention provides for use of antisense molecules in pharmaceutical compositions for treatment of diseases associated with the expression of MCPP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or transcripts of MCPP and anti-MCPP antibodies which specifically bind to MCPP.