| 发明名称 |
Inhibitors of receptor activator of NF-kappaB and uses thereof |
| 摘要 |
The present invention provides a RANK (receptor activator of NF-kappaB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.
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| 申请公布号 |
US2003013170(A1) |
申请公布日期 |
2003.01.16 |
| 申请号 |
US20020143293 |
申请日期 |
2002.05.10 |
| 申请人 |
AGGARWAL BHARAT;DARNAY BRYANT G.;SINGH SUJAY |
发明人 |
AGGARWAL BHARAT;DARNAY BRYANT G.;SINGH SUJAY |
| 分类号 |
C12N15/09;A61K38/00;A61K45/00;A61P15/00;A61P19/02;A61P19/08;A61P35/00;A61P35/02;A61P35/04;C07K7/06;C07K7/08;C07K14/47;C07K14/705;C12N9/12;(IPC1-7):A61K38/16;C12N9/99 |
主分类号 |
C12N15/09 |
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