| 主权项 |
1. A device for characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the device comprising:
a microfluidic device having a microfluidic chamber suitable for receiving a sample of said fluid and enabling it to be illuminated; a lighting means positioned relative to the microfluidic device to illuminate said microfluidic chamber and said sample by a spatially coherent light beam; a two-dimensional matrix image detector configured and arranged relative to the microfluidic device to acquire a time series of two-dimensional images of said sample, said two-dimensional images including an optical speckle pattern generated by interaction between said sample and said spatially coherent light beam, wherein said two-dimensional images include pixels; and a non-transient computer readable memory programmed with a computer software, the software configured, with a processor, to: obtain a series of two-dimensional images from said two-dimensional matrix image detector; analyze, pixel by pixel, pairs of images of the series, wherein the analysis include calculating, for each pair of images, an overall value based on a difference between pixels of images of said pair of images or on a correlation of images of said of pair of images; derive a function based on the overall value calculated for each pair of images, and characterize one or more of the coagulation or sedimentation of said fluid based on said function. |
