MEDICINE COMPOSED OF 5-MEMBERED RING COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a medicine effective for inhibiting the infiltration of leukocyte such as acidophilic leukocyte and lymphocyte and useful for the treatment of various inflammatory diseases. SOLUTION: The medicine contains a 5-membered ring compound or its salt expressed by formula [X is O or S; R1is H, a substituted or unsubstituted alkyl or the like; R2is H, a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl or the like; Y1is single bond, a substituted or unsubstituted alkylene, CO(CH2)nor the like; the wavy line is (E) or (Z) configuration; R3is a substituted or unsubstituted aryl or the like; Y2is a substituted or unsubstituted alkylene or the like; R4is H, a substituted or unsubstituted alkanoyl, a substituted or unsubstituted alkyl or the like; R5is H or the like). COPYRIGHT: (C)2003,JPO