| 主权项 |
1. A compound of Formula (I): wherein R1 and R3 are independently from each other selected from the group consisting of H and linear or branched C1-C6-alkyl, R2 is selected from the group consisting of chloro, linear or branched C1-C6-alkyl and C3-C7 cycloalkyl, R4 is selected from the group consisting of F and H, and R5 is selected from the group consisting of A and CH2CH2R7, wherein A is selected from the group consisting of:wherein
R6 is selected from the group consisting of H, CH3, CH2CH2R, CH(CH2R)2, CH2CR3, CH2-cyclopropyl, CH2CN, and CH2CHF2, R6′ is selected from the group consisting of CH2CH2R′, CH(CH2R′)2, CH2CR3, and CH2CO2R1, R6″ is selected from the group consisting of F, OH, OCH3, NH2, N(CH3)2, N(R1)2, and CO2R1, R6′″ is selected from the group consisting of CH2CH2R, CH(CH2R)2, CH2CR3, CH2-cyclopropyl, CH2CN, and CH2CHF2, R is selected from the group consisting of H, CN, OH, OCH3, Cl, F, CHF2, CH3, CF3, CH2CH3 and cyclopropyl, R′ is selected from the group consisting of CN, OH, OCH3, Cl, CHF2, CH3, CF3 and cyclopropyl, and R7 is selected from the group consisting of: wherein Ra and Rb are each independently selected from the group consisting of H, F, CH3, OCH3, OH and 1-pyrrolidinyl and at least one of Ra and Rb is selected from the group consisting of F, CH3, OCH3, OH and 1-pyrrolidinyl, or tautomers, salts, solvates, stereoisomers, diastereomers and enantiomers thereof. |
