| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein n is 1, 2, or 3;m is 0, 1, 2, 3, 4, 5, 6, 7, or 8; provided that (i) when n is 1, m is 0, 1, 2, 3, or 4; (ii) when n is 2, m is 0, 1, 2, 3, 4, 5, or 6; and (iii) when n is 3, m is 0, 1, 2, 3, 4, 5, 6, 7, or 8;each R is independently halo or (C1-C4) alkyl;each Y is CR3;each R3 is independently hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, amino, amido or thiol;B is (i) R4 and R5 together with the atoms to which they are attached form a monocyclic or multicyclic aryl, heteroaryl, cycloalkyl, or heterocyclyl ring; or (ii) R4 and R5 are each independently hydrogen, cyano, halo, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aralkyl, heteroaralkyl, heteroaryl, heterocyclyl, hydroxy, amino, imino, amido or thiol;
B1 is O, S, or NR8;B2 is CR9 or N;R6 is hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, amino, amido or thiol;R7 is hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl;R8 is hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; andR9 is hydrogen, halo, cyano, alkyl, alkenyl, alkoxy, aminoalkyl, heteroalkyl, cycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, heterocyclyl, amino, amido or thiol;provided that a compound of formula (I) is not: |
