| 发明名称 | Histone deacetylase inhibitors and compositions and methods of use thereof | ||
| 摘要 | Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.; | ||
| 申请公布号 | US9505736(B2) | 申请公布日期 | 2016.11.29 |
| 申请号 | US201314414149 | 申请日期 | 2013.07.16 |
| 申请人 | CHDI Foundation, Inc. | 发明人 | Dominguez Celia;Breccia Perla;Luckhurst Christopher A.;Bürli Roland W.;Stott Andrew J. |
| 分类号 | C07D319/18;C07D213/74;C07D311/58;C07D401/04;C07D237/08;C07D239/26;C07D239/30;C07D239/34;C07D241/12;C07D417/04;C07D263/32;C07D277/30;C07D213/56;C07D213/61;C07D263/56;C07D215/18;C07D277/64;C07D295/155;C07C259/08 | 主分类号 | C07D319/18 |
| 代理机构 | Sheppard Mullin Richter & Hampton LLP | 代理人 | Sheppard Mullin Richter & Hampton LLP |
| 主权项 | 1. A compound of Formula I or a pharmaceutically acceptable salt thereof wherein: R1 and R2 are independently chosen from optionally substituted aryl and optionally substituted heteroaryl; R3 is chosen from —C(O)NH(OH) and —N(OH)C(O)R4; R3a is halo; and R4 is chosen from hydrogen and lower alkyl. | ||
| 地址 | New York NY US | ||