发明名称 |
Process for producing erythromycin derivative |
摘要 |
There is provided a preparation process useful for an efficient synthesis of 6-O-substituted ketolide derivatives by combining a characterized step of introduction of a substituent at the 6-position by selective cleavage of a C-O bond of the cyclic acetal at the 9-position side via 6,9-cyclic acetal 5-O-desosaminyl erythronolide derivative, a step of conversion into carbonyl groups at the 9- and 3-positions, and a step of 11,12-cyclic carbamation to lead to 6-O-substituted ketolide derivatives.
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申请公布号 |
US2003191295(A1) |
申请公布日期 |
2003.10.09 |
申请号 |
US20030344529 |
申请日期 |
2003.02.12 |
申请人 |
KASHIMURA MASATO;KAMIYAMA HIROAKI;KUWADA TAKESHI;SUZUKI NOBUYUKI;ADACHI TAKASHI |
发明人 |
KASHIMURA MASATO;KAMIYAMA HIROAKI;KUWADA TAKESHI;SUZUKI NOBUYUKI;ADACHI TAKASHI |
分类号 |
C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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