发明名称 Culture containers with internal top coating over gas barrier coating and associated methods
摘要 A container for culturing a test sample includes a molded monolithic single layer polymeric container body having an upwardly extending, visually transmissive wall with an inner surface and a wall thickness that is between about 0.2 mm and 10 mm. The container also has a thin gas barrier coating comprising silica on the inner surface of the sealed container body and an internal top coating on the gas barrier coating. The gas barrier and top coating are visually transmissive (after curing). The container includes a cap sealably attached to the container body. The sealed container has an oxygen transmission rate (OTR) after autoclaving and aging that is between about 0.0001 to about 0.04 (cc/package/day/atm).
申请公布号 US9523110(B2) 申请公布日期 2016.12.20
申请号 US201313789940 申请日期 2013.03.08
申请人 bioMerieux, Inc. 发明人 Wolters Weihua Sonya;Philipak Stanley Michael
分类号 C12M3/00;C12M1/34;C12Q1/04;C12M1/24;C12M1/00 主分类号 C12M3/00
代理机构 Myers Bigel, P.A. 代理人 Myers Bigel, P.A.
主权项 1. A container for culturing a test sample, comprising: a molded monolithic single layer polymeric container body having an upwardly extending, visually transmissive wall with an inner surface and a wall thickness that is between about 0.2 mm and 10 mm; a thin gas barrier coating having a thickness between about 1 nm and 1000 microns comprising silica on the inner surface of the container body, wherein the gas barrier coating is visually transmissive; an internal top coating directly on the gas barrier coating, wherein the internal top coating is visually transmissive and the internal top coating is selected from the group consisting of a polyester, polyvinylidene chloride (PVDC), polyvinyl alcohol (PVOH), poly(acrylonitrile) (PAN), polyamide (PA), a polyurethane, an acrylic polymer, a polyetheramine, a metal oxide, a polypropylene film with reprocessed/recycled polyhydroxyamino ether (PHAE), a poly-para-xylylene polymer, acetylene, and any combination thereof; and a cap sealably attached to the container body to define a sealed container, wherein the sealed container has an oxygen transmission rate (OTR) after exposure to 121 degrees C. for 15 minutes and throughout a one year shelf life that is between about 0.0001-0.04 (cc/package/day/atm, measured at 20 degrees C., 40% RH), and wherein the container body has only two inner coating layers, the gas barrier coating as a first inner coating layer and the internal top coating as a second inner coating layer.
地址 Durham NC US